Supplements to optimize insulin and blood sugar levels, to increase lean body mass and decrease body fat levels.
A modified version of insulin, capable of precisely regulating the amount of sugar absorbed by the tissues so as to lower blood sugar only to normal levels and not beyond. Taking an incorrect amount of insulin can in fact lead to an excessive drop in blood sugar, with negative consequences for the body. To avoid this risk, the researchers attached a glucose transporter (GLUT) inhibitor to I-insulin: when blood sugar levels drop too low, the hormone partially blocks the absorption of sugar within the cells, leaving it in the blood and thus preventing hypoglycemia. In this way, in essence, patients are provided with an insulin “reserve” that would be used only when the blood sugar level is high and which instead, as the blood sugar level drops to normal levels, would become less active lowering the risk of causing hypoglycemia.
The new insulin works as a smart key – clarified the lead author of the study, researchers – allows glucose to enter the cells, but prevents their excessive absorption when the blood sugar has reached normal levels. Not only that, the new online insulin would also react promptly to hyperglycemia.
Is Insulin good or bad? Many people talk about control of blood sugar levels, through precise food strategies, to make the best use of their endogenous insulin and not to accumulate fat, keeping energy levels stable during the day, without sudden episodes of hunger or weakness. While other people say instead of following zero carbohydrate diets, to always keep insulin levels to a minimum. But can insulin seriously help to gain muscle mass? Or will it only make me accumulate more body fat? Insulin is a hormone that has been widely discussed in the bodybuilding and fitness environment and in scientific communities. Now it’s time to understand exactly how the insulin actually works?
Let’s dive into the “mechanism” of insulin functioning, including some brief and simple hints of biochemistry, and let’s see exactly how it works in the body and what its metabolic effects are. Insulin is a peptide hormone released by the beta cells of the pancreas. It is secreted in response to an increase in blood sugar levels, mainly induced by the intake of food carbohydrates, although, to a lesser degree, certain amino acids, present in protein sources, still determine their release.
Insulin hormone is primarily responsible for coordinating energy metabolism in response to a meal. Insulin helps regulate blood sugar levels, the so called blood sugar, helping to amnetenrla in the range of 55-120mg / dl of blood. Individuals with metabolic pathologies such as type I diabetes and type II diabetes mellitus cannot produce endogenous insulin, so they must necessarily inject it in order to simulate certain sensitivity to insulin. Insulin binds to specific receptors that are found on cell membranes and that help carry glucose from the outside to the inside of the cell.
Normally cell membranes are impermeable to glucose, but when a cell receptor is activated, the membranes allow an almost instantaneous entry of glucose into the cells. Insulin helps the activation of glycogen, this causes glucose to be stored in the form of glycogen within the muscle tissue (two thirds of the total glycogen are stored in the muscles, while the remaining third is stored in the liver). Hepatic glycogen is mainly used to keep blood sugar stable, and therefore circulating glucose levels in the blood.
Insulin allows cell membranes to become permeable to glucose, certain amino acids such as creatine and some minerals. Insulin causes specific glucose transport proteins (GLUT) to increase their activity thus allowing a greater flow of glucose into the cell. Two of these specific transporters have been found in the skeletal mucol: the GLUT present in smaller quantities and the GLUT, which is the most present isoform, and is responsible for the increase in the transport of glucose in response to insulin and muscle contractions. In fact, it seems that in skeletal muscle, both insulin and exercise can stimulate a migration of GLUT transports from
Although insulin helps direct blood glucose supplies within the muscles and liver, in the form of glycogen, it can also convert excess sugar into fat. Insulin is really a double-edged sword. In fact, it can increase the accumulation of fat and the synthesis of fatty acids by triggering the activity of the enzyme lipase and acetyl decarboxylase. What many people don’t know is that insulin increases the entry of amino acids into muscle tissue, thus allowing the muscles to have a greater availability of amino acids in order to recover and grow. Thus, we have before us a hormone that can help us in the glycogen resynthesis, also creating a more conducive environment for growth, without mentioning the cell volumizing effect that follows. All this can also cause a moisturizing effect of the cells that can give more energy. Some athletes also report better muscle pumping when using supplements that maximize insulin levels.
The insulin hormone antagonist is glucagon, the latter being activated when blood glucose levels are too low. Glucagon, exactly the opposite of what insulin does, is able to degrade muscle protein and reduce the glycogen stores it contains, so it is important to control it.
The release of insulin is also able to allow a greater transport of creatine inside the muscle cell. For this reason, it has been theorized that taking humalog insulin mimetic supplements may help the transport and absorption of creatine. To get more specific information, however, it will be necessary to wait for further research. Results of the study conclude that there is a high prevalence of insulin resistance in the first degree relatives of diabetes mellitus. ALT levels in the first degree relatives of diabetes mellitus had increased levels of insulin resistance, the pathogenesis suggesting increase in ALT levels as seen in insulin resistance condition. In our study, ALT was not statistically significant.